A blood clot can also form in the main blood vessel that leads to the liver. J Mol Diagn. As a chronic condition, PV needs long-term management. Conclusion: COPD Patients had a significant prevalence of secondary polycythemia, and ignoring this may lead to complications. 2013 Jul-Aug. 19 (4):363-6. Patakas DA, Christaki PI, Louridas GE, Sproule BJ. To prevent those problems, your doctor will recommend treatments to improve your blood flow and help you feel better. [Full Text]. Deep vein thrombosis (DVT) is a clot in a vein deep inside your leg. AU - Gallagher, Christopher J. [Medline]. Shortness of breath 6. Passamonti F. How to manage polycythemia vera. Enlarged spleen. Khan, F. Anaesthesia, Pain & Intensive Care, 2012. Possible complications of polycythemia vera include: 1. Ip F, di Pierro I, Brown R, et al. [Medline]. The incidence outside the United States is not well documented but likely to be higher due to the pregnancy complications outlined below that result in fetal/neonatal polycythemia. Some people with PV -- about 4 out of 10 -- have itchy skin. Kralovics R, Indrak K, Stopka T, et al. About complications: Complications of Polycythemia are secondary conditions, symptoms, or other disorders that are caused by Polycythemia. A guideline for the diagnosis and management of polycythaemia vera. Some patients with extreme secondary polycythemia have impaired alertness, dizziness, headaches, and compromised exercise tolerance. This website also contains material copyrighted by 3rd parties. It can be due to an increase in the number of red blood cells ("absolute polycythemia") or to a decrease in the volume of plasma ("relative polycythemia"). The thick, viscous blood causes sluggish circulation, blocks vessels, and interferes with oxygen delivery to the cells that may result in the following symptoms: 1. Other causes of secondary polycythemia such as chronic hypoxia, chronic kidney disease and obstructive sleep apnea were investigated and determined to not be the cause of polycythemia. Increased blood thickness and decreased blood flow, as well as abnormalities in your platelets, increase your risk of blood clots. [Medline]. Secondary polycythaemia is where an underlying condition causes more erythropoietin to be produced. Nested high-resolution melting curve analysis a highly sensitive, reliable, and simple method for detection of JAK2 exon 12 mutations--clinical relevance in the monitoring of polycythemia. The disease is often discovered during a routine blood test or physical examination. Blood Rev. Médicament 2020. Doctors treat ulcers and prevent new ones from forming with medicines that curb acid production, such as proton pump inhibitors or H2 blockers. 3 secondary polycythemia … Polycythemia refers to an absolute increase of red blood cell counts or mass. 2. Am J Physiol Endocrinol Metab. Secondary Polycythemia . The JAK-2 mutation is found to be present in over 90% of patients with polycythemia vera. 1982 Oct;76(4):313-40. doi: 10.1016/0007-0971(82)90067-5. This can happen in different places in your body. 1999 Mar. La polyglobulie econdaire, emblable à la polyglobulie primaire, et un trouble qui provoque une urproduction de globule rouge. 1982 May. Study Objective: To determine the effects of secondary polycythemia on perioperative hemorrhagic and thrombotic complications. It's usually caused by a change in the JAK2 gene, which causes the bone marrow cells to produce too many red blood cells. This is the same chemical your body releases during an allergic reaction. 2015 Apr. Itching (pruritus) 8. [Medline]. The secondary polycythemic patients were compared with the matched control group and did not have a higher frequency of these complications. Blood clots can cause a stroke, a heart attack or a blockage of an artery in your lungs (pulmonary embolism) or in a vein deep within a muscle (deep vein thrombosis). Complications of treatment include bleeding, especially gastrointestinal haemorrhage and, in particular, variceal ... Ivana Vučinić Ljubičić, Božena Coha, Higher red blood cell distribution width might differentiate primary from secondary polycythemia: A pilot study, International Journal of Laboratory Hematology, 10.1111/ijlh.13373, 0, 0 , (undefined). This can lead to acute myelogenous leukemia, a cancer of the blood and bone marrow. American Association for Cancer Education, American College of Clinical Pharmacology, American Association for the Advancement of Science, American Clinical and Climatological Association, International Society of Blood Transfusion, International Society on Thrombosis and Haemostasis, Royal College of Physicians and Surgeons of Canada. Thromboembolic complications of polycythemia: polycythemia vera versus smokers' polycythemia. One of its main jobs is to recycle old red blood cells. Secondary Polycythemia . 2009 May. How bad it is. WebMD does not provide medical advice, diagnosis or treatment. Secondary polycythemia occurs when the body is not getting enough oxygen or as a response to certain drugs or hormones. - What Complications Happen With Polycythemia Vera? The classification and diagnosis of erythrocytosis. If you get an ulcer, you'll likely have stomach pain, along with nausea, vomiting, and a feeling of fullness. [Medline]. [Medline]. Sex Med Rev. The complete evaluation of erythrocytosis: congenital and acquired.  Other causes testosterone replacement therapy  and heavy cigarette smoking. Blood carries oxygen around your body. Erslev AJ, Caro J. Pediatrics. Objective: Secondary polycythemia is an important complication of chronic obstructive pulmonary disease (COPD) but its frequency of occurrence is unknown in our setup. Gonzales GF, Gasco M, Tapia V, Gonzales-Castañeda C. High serum testosterone levels are associated with excessive erythrocytosis of chronic mountain sickness in men. Design: Retrospective chart review. … Br J Haematol. The goal is to avoid complications like blood clots, which may happen because PV thickens your blood. [Full Text]. ", National Heart, Lung, and Blood Institute: "How Is Polycythemia Vera Treated?" secondary polycythaemia – too many red blood cells are produced as the result of an underlying condition ; Polycythaemia vera (PV) PV is rare. ", Medscape: "Polycythemia Vera Clinical Presentation," "Polycythemia Vera Treatment & Management. Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American Society of Clinical Oncology, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Hematology, New York Academy of SciencesDisclosure: Nothing to disclose. The gums and small cuts are likely to bleed, and the hands and feet may burn. The secondary polycythemic patients were compared with the matched control group and did not have a higher frequency of these complications. Lorque trop de globule rouge ont produit, le … 2009 Nov 10. [Medline]. Jones SD Jr, Dukovac T, Sangkum P, Yafi FA, Hellstrom WJ. At extreme levels of secondary polycythemia, patients can be at risk for thrombosis. Schwarcz TH, Hogan LA, Endean ED, et al. 1. This is similar to giving blood during a blood drive. Its symptoms may include: To prevent clots, your doctor will remove a small amount of blood with a treatment called phlebotomy. Patient demographics and outcomes after therapy were evaluated. The risk factors for secondary polycythemia (erythrocytosis) are: [Full Text]. Histamine makes your skin itch. Visual disturbances associated with this disorder include distorted vision, blind spots, and flashes of light. Remacha AF, Montserrat I, Santamaria A, et al. For a more detailed analysis of Polycythemia as a symptom, including causes, drug side effect causes, and drug interaction causes, please see our Symptom Center information for Polycythemia. Sometimes polycythemia vera prompts your body to make extra platelets. 2009 May. It was not known if secondary polycythemia caused by smoking carries the same risk of developing thromboembolic complications as does PV. Many patients with PV remain asymptomatic for years owing to the extremely slow development of this disease and are found incidentally on routine blood counts revealing increased hemoglobin levels. You may also feel fatigued and have dark, tarry stools. Ringing in the ears (tinnitus) 12. Read on to find out more about polycythemia, its pathophysiology , primary polycythemia or polycythemia vera , secondary polycythemia , etiology & epidemiology , diagnosis & complications , treatment & prevention & prognosis . Secondary polycythemia can be a complication of hypoxic disease, in which oxygen levels in the blood are low, or of genetic mutations or kidney or liver tumors. Eur J Endocrinol. What Is Polycythemia Vera? Leukemia. Again, these problems aren’t likely. 7(5):334-42. Symptoms and Complications. If symptoms do develop, they tend to do so over time. A case report of strokes in two patients, 42 and 45 years old, with smokers' polycythemia raised the question of whether … Secondary polycythemia: It occurs due to some physiological changes which increased the oxygen demand by the body like lung disease, high altitude and severe obesity. However, treatment with phlebotomy is indicated for patients with hematocrits higher than 60%-65%, who may experience symptoms such as impaired alertness… [Full Text]. This is a hormone produced by the kidneys that stimulates the bone marrow cells to produce red blood cells. Secondary polycythemia is usually caused by an exposure to low oxygen over an extended amount of time. Polycythemia vera (also called primary polycythemia) is a rare growth disorder of the bone marrow, occurring when the marrow is overactive and produces more blood cells than the body needs. Secondary polycythemia. PMID: 6758830 DOI: 10.1016/0007-0971(82)90067-5 No abstract available. Control of breathing in patients with chronic obstructive lung diseases and secondary polycythemia after venesection. Semin Hematol. Secondary polycythaemia: its causes, effects and treatment. Ronald A Sacher, MBBCh, FRCPC, DTM&H Professor of Internal Medicine and Pathology, Director, Hoxworth Blood Center, University of Cincinnati Academic Health Center A follow-up study. It can be due to an increase in the number of red blood cells or to a decrease in the volume of plasma. Polycythemia. Your doctor might need to change your medicine until the bleeding is under control. 296(6):E1319-25. Signs that your body isn't getting enough oxygen include: PV treatments can improve blood flow and oxygen transport to prevent these symptoms. Karen Seiter, MD is a member of the following medical societies: American Association for Cancer Research, American College of Physicians, American Society of HematologyDisclosure: Received honoraria from Novartis for speaking and teaching; Received consulting fee from Novartis for speaking and teaching; Received honoraria from Celgene for speaking and teaching. Br J Haematol. AU - Berend, Julia L. PY - 1991/1/1. Secondary polycythemia. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly93d3cubWVkc2NhcGUuY29tL2Fuc3dlcnMvMjA1MDM5LTc2MTI0L3doYXQtYXJlLWNvbXBsaWNhdGlvbnMtb2Ytc2Vjb25kYXJ5LXBvbHljeXRoZW1pYQ==. Thromboembolic complications of polycythemia: polycythemia vera versus smokers' polycythemia. Secondary Polycythemia was found in 26 (10.8%) patients. Patients may feel lightheaded or experience shortness of breath. It was not known if secondary polycythemia caused by smoking carries the same risk of developing thromboembolic complications as does PV. This rare condition is called Budd-Chiari syndrome. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. Rev Med Interne. Haematologica. There are many potentially modifiable risk factors to prevent secondary polycythemia. Secondary polycythemia results from excess stimulation of erythropoiesis, mainly due to elevated serum levels of erythropoietin.… Secondary Polycythemia: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and … It’s the clotting of blood in your arteries or veins. Int J Lab Hematol. Clin Adv Hematol Oncol. Secondary polycythaemia. Nadeem O, Gui J, Ornstein DL. They may have: If you take aspirin to prevent clots, it could make the bleeding worse. Common symptoms reported by people with secondary polycythemia. Sara J Grethlein, MD, FACP Professor of Clinical Medicine, Indiana University School of Medicine; Medical Director of Cancer Services, Indiana University Health, Adult Academic Health Center, IU Simon Cancer and IU North Hospital, Joe and Shelly Schwarz Cancer Center CCI was used assess CV morbidity burden (low risk ≤4 vs high risk >4). [Medline]. They prevent your blood from clotting the way it should. Ronald A Sacher, MBBCh, FRCPC, DTM&H is a member of the following medical societies: American Association for the Advancement of Science, American Association of Blood Banks, American Clinical and Climatological Association, American Society for Clinical Pathology, American Society of Hematology, College of American Pathologists, International Society of Blood Transfusion, International Society on Thrombosis and Haemostasis, Royal College of Physicians and Surgeons of CanadaDisclosure: Nothing to disclose. If symptoms do develop, they tend to do so over time. Secondary polycythaemia: its causes, effects and treatment Br J Dis Chest. Erythropoietin-secreting tumors (eg, hepatocellular carcinoma, renal cell carcinoma, adrenal a… 17(3):518-22; discussion 522-3. Enlarged spleen (splenomegaly). Visual disturbances 7. Am Rev Respir Dis. If your spleen is enlarged, you may have symptoms like: If your enlarged spleen causes problems, you may need to take medicine for it, or you may need surgery to remove it. 2009 Jun. After years of pumping out extra red blood cells, your bone marrow can become so filled with scar tissue that it can't make enough blood cells to meet your body's needs. From there, it can move into your lung and get stuck. ", National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Questions and Answers About Gout. The risk is lower than with primary erythrocytosis but data are too sparse for accurate quantification. Balcerzak SP, Bromberg PA. PMID: 1105791 [Indexed for MEDLINE] Publication Types: 1981 May. The term polycythemia is used appropriately in the myeloproliferative disorder called polycythemia vera , in which there are elevated levels of all three peripheral blood cell lines—RBCs, white blood cells, and platelets. The term polycythemia is used appropriately in the myeloproliferative disorder called polycythemia vera, in which there are elevated levels of all three peripheral blood cell lines—RBCs, white blood cells, and platelets. Schwarcz TH, Hogan LA, Endean ED, et al. Polycythemia is defined as an abnormal increase in the red blood cell mass. 2008 Dec. 30(6):447-59. Polycythemia vera is an uncommon condition It occurs more often in men than in women. [Medline]. A case report of strokes in two patients, 42 and 45 years old, with smokers' polycythemia raised the question of whether … Polycythemia vera (PV) and essential thrombocythemia (ET) are 2 chronic myeloproliferative diseases (cMPDs) 1 with clinical courses that are characterized by a low rate of transformation into acute myeloid leukemia and myelofibrosis, 2, –4 a long median survival, and an increased risk of venous and arterial thrombosis and of hemorrhage. Its exceptional association with pregnancy can lead to severe complications. ", University of Iowa Hospitals & Clinics: "Polycythemia Vera.". They’re more likely if you’re older than 60 or have already had a blood clot or complication. Leukemia & Lymphoma Society: "Myelofibrosis Facts. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. One of its jobs is to filter worn out... High levels of red blood cells. 1. You get gout when cells turn over too quickly in your body -- like in PV. Secondary Polycythemia. 2003 Oct. 123(2):371-2. The disease is often discovered during a routine blood test or physical examination. Esparcieux A, Francina A, Vital-Durand D. [Abnormal haemoglobins with high oxygen affinity in the differential diagnostics of polycythemia]. Or it can block a blood vessel in the heart and cause a heart attack. Increased synthesis of red blood cells is called polycythemia. [Medline]. Background: Polycythemia is characterized by rise in hemoglobin and hematocrit, either as a result of hematopoietic clonal expansion (Vera) or secondary to hypoxic stimuli (secondary polycythemia).It is of great importance to detect early and identify the type of polycythemia and also asses the thrombotic risk so that timely and appropriate treatment can be given. Common complications include slower blood flow and development of blood clots. Red blood cell transfusion requirements for patients with secondary polycythemia were less than that for the matched controls (p < 0.005). Red blood cell transfusion requirements for patients with secondary polycythemia were less than that for the matched controls (p < 0.005). Prchal JF, Prchal JT. Clinical Spectrum and Complications of Polycythemia, in Patients presenting at Tertiary Care Centre at Goa October 2019 The Journal of the Association of Physicians of India 67(10):20-24 When PV slows blood flow, it's hard for oxygen to reach your organs. Two new EPO receptor mutations: truncated EPO receptors are most frequently associated with primary familial and congenital polycythemias. At extreme levels of secondary polycythemia, patients can be at risk for thrombosis. Serum erythropoietin in the diagnosis of polycythemia vera. Cigarette smoking and secondary polycythemia in hypoxic cor pulmonale. Your spleen is in the upper left part of your abdomen. Blood clots can cause a stroke, a heart attack, or a blockage in an artery in your lungs or a vein deep within a leg muscle or in the abdomen. If you log out, you will be required to enter your username and password the next time you visit. Methods: A retrospective review of 143 patients with secondary polycythemia was conducted between December 2003 and March 2017. DESIGN: Retrospective chart review. Prevalence of venous thromboembolism in patients with secondary polycythemia. J Pediatr Hematol Oncol. Symptoms of secondary polycythemia are the same as those for primary polycythemia and may include: 1. Srikanth Nagalla, MBBS, MS, FACP Associate Professor of Medicine, Division of Hematology and Oncology, UT Southwestern Medical Center Polycythemia is sometimes called erythrocytosis, but the terms are not synonymous, because polycythemia refers to any increase in red blood mass, whereas erythrocytosis only refers to a documented increase of red cell count. Your doctor may recommend an antihistamine or low-dose aspirin. Platelets normally help your blood clot, but the extra ones in PV don't always work well. [Medline]. 1997 Jul-Aug. 82(4):406-10. Thrombosis is one of the most serious concerns in PV. Doctors call this condition myelofibrosis. Patnaik MM, Tefferi A. Your doctor can prescribe medicines such as allopurinol to control gout and prevent future attacks. Secondary polycythemia results from excess stimulation of erythropoiesis, mainly due to elevated serum levels of erythropoietin.… Secondary Polycythemia: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and … It's caused by the buildup of uric acid in your joints. "What Are the Signs and Symptoms of Polycythemia Vera? Secondary polycythemia is a rare disorder where there are too many red blood cells in your blood. It is rarely seen in people under the age of 40. Depending on the cause, polycythemia can be classiﬁed into two major types: Primary Polycythemia: It is also called Polycythemia Vera (PV). Secondary polycythemia can be caused by a variety of erythropoietin-producing renal lesions and cancers. 1982 May. STUDY OBJECTIVE: To determine the effects of secondary polycythemia on perioperative hemorrhagic and thrombotic complications. Familial and congenital polycythemias: a diagnostic approach. ", The Myeloproliferative Disorders Research Consortium: "FAQ: About Polycythemia Vera. J Vasc Surg. Lee FS. It also occurs due to the increased levels of an RBC-stimulating hormone called erythropoietin. Antithrombotic treatment could prevent such adverse outcome. Sara J Grethlein, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physician Executives, American College of Physicians, American Medical Women's Association, American Society of Clinical Oncology, American Society of Hematology, Gold Humanism Honor Society, Leukemia and Lymphoma SocietyDisclosure: Nothing to disclose. Many people with polycythemia vera (PV) live a normal life with this rare blood cancer under control. Secondary polycythemia: a boon or a burden? Pain in the chest or leg muscles 9. Secondary polycythemia. You may also get medicines like low-dose aspirin, hydroxyurea, or interferon alfa to thin your blood and stop your body from making too many blood cells. Please confirm that you would like to log out of Medscape. A rise in histamine levels also causes your stomach to make more acid. for: Medscape. A headache, dizziness, and fatigue 2. Disease Complications Blood Clots Causes Of Polycythemia. Secondary polycythemia is limited to overproduction of red cells. Gout is a type of arthritis. Evidence used in this review. Schwarcz TH, Hogan LA, Endean ED, et al. Calverley PM, Leggett RJ, McElderry L, Flenley DC. Authors B D Harrison, T C Stokes. Background: Polycythemia is characterized by rise in hemoglobin and hematocrit, either as a result of hematopoietic clonal expansion (Vera) or secondary to hypoxic stimuli (secondary polycythemia).It is of great importance to detect early and identify the type of polycythemia and also asses the thrombotic risk so that timely and appropriate treatment can be given. 1993 Mar. Symptoms and Complications. The emergency treatment of polycythemia is by phl At extreme levels of secondary polycythemia, patients can be at risk for thrombosis. 6(2):100-9. 2019 Jan. 184 (2):176-191. Polycythemia refers to an absolute increase of red blood cell counts or mass. CD006503. Signs of gout include swelling and pain in your joints, especially in your big toe. Weakness, headaches, and fatigue are usually the first symptoms of secondary polycythemia. [Medline]. Van Maerken T, Hunninck K, Callewaert L, et al. Sometimes a clot gets loose and travels through a blood vessel. complications. How bad it is. polycythemia Vera, secondary polycythemia and relative polycythemia. 2008 Apr 16. Many people with polycythemia vera (PV) live a normal life with this rare blood cancer under control. Out of these confirmed case females constitute 11 (4.6%) while rest 15 (6.32%) were male. 1975 Oct;12(4):353-82. Study Objective: To determine the effects of secondary polycythemia on perioperative hemorrhagic and thrombotic complications. 13(3):263-70. Semin Hematol. All that extra work makes the spleen grow bigger. Blood. This is a pulmonary embolism, and it’s an emergency. Wiley Online Library. Secondary polycythemia is caused by factors other than abnormal clone of erythroid proginators. Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets. [Medline]. All rights reserved. 67(5):667-70. polycythemia caused by smoking (n = 27) was based on an elevated total red blood cell volume, decreased oxygen saturation on arterial blood gas measurement, evidence of chronic obstructive pulmonary disease, and elevated carboxyhemoglobin levels. Polycythemia vera is a rare chronic myeloproliferative disease. Secondary polycythemia affects some people as a result of limited oxygen due to smoking or living at high altitudes. American College of Gastroenterology: "Peptic Ulcer Disease. Karen Seiter, MD Professor, Department of Internal Medicine, Division of Oncology/Hematology, New York Medical College Keep the water cool when you shower or take a bath. Design: Retrospective chart review. 1975 Oct. 12(4):353-82. Secondary polycythemia would more accurately be called secondary erythrocytosis or erythrocythemia, as those terms specifically denote increased red blood cells. [Medline]. [Medline]. © 2005 - 2019 WebMD LLC. Setting: Surgical patients at a university-affiliated Veterans Administration Hospital. [Full Text]. [Medline]. Respiration. Burning sensations of the hands or feet About 3 out of 4 people with PV have an enlarged spleen. Thromboembolic complications of polycythemia: polycythemia vera versus smokers' polycythemia. Many people have no symptoms when they are first diagnosed with polycythaemia vera. Sondel PM, Tripp ME, Ganick DJ, Levy JM, Shahidi NT. They may … ", MPN Research Foundation: "What is Primary Myelofibrosis (MF)? Srikanth Nagalla, MBBS, MS, FACP is a member of the following medical societies: American Society of Hematology, Association of Specialty ProfessorsDisclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Alexion; Alnylam. Zhan H, Spivak JL. Complications of secondary polycythemia are typically related to those of the underlying disease. [Medline]. However, the associated increase in viscosity tends to decrease blood flow and in theory should augment rather than relieve tissue hypoxia. Curr Opin Hematol. When overproduced, erythropoietin can cause thickening of the blood, leading to the symptoms of polycythemia. Am Rev Respir Dis. Setting: Surgical patients at a university-affiliated Veterans Administration Hospital. Secondary polycythemia would more accurately be called secondary erythrocytosis or erythrocythemia, as those terms specifically denote increased red blood cells. Secondary polycythemia - also called reactive polycythemia - is characterized by excessive production of circulating red blood cells (RBCs) due to hypoxia, tumor, or disease.It occurs in about 2 out of every 100,000 persons who live at or near sea level; incidence increases among people who live at high altitudes. Genetic causes of erythrocytosis and the oxygen-sensing pathway. Pillai AA, Babiker HM. This acid can leave sores called peptic ulcers in the lining of your esophagus, stomach, or small intestine. 23(5):834-44. Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug ReferenceDisclosure: Received salary from Medscape for employment. Fatigue 4. [Medline]. The incidence outside the United States is not well documented but likely to be higher due to the pregnancy complications outlined below that result in fetal/neonatal polycythemia. 2011 May. Carillo S, Henry L, Lippert E, Girodon F, Guiraud I, Richard C, et al. Polycythemia is defined as an abnormal increase in the red blood cell mass. Typical findings for polycythemia: In many children the only manifestation will be plethora. 3 (2):101-112. Uric acid forms into hard crystals that leave the joints sore and swollen. Leukemia. Strokes due to increased erythrocytosis (also reported in the anabolic steroid use in athletes)  Doctors call this “splenomegaly.”. Phlebotomy with iron therapy to correct the microcytic polycythemia of chronic hypoxia. SETTING: Surgical patients at a university-affiliated Veterans Administration Hospital. Secondary polycythemia is different from polycythemia vera in several ways. Most of the symptoms of PV occur due to the increased blood viscosity, secondary to increased red blood cell mass. Y1 - 1991/1/1. When this occurs, your blood becomes thick, which makes it difficult for the blood to flow through your smaller blood vessels. Confusion 11. 2011 Oct. 32(10):e105-7. Primary polycythemia vera was also unlikely given the normal EPO value and negative JAK-2. Cigarette smoking and secondary polycythemia in hypoxic cor pulmonale. [Medline]. The risk is lower than with primary erythrocytosis but data are too sparse for accurate quantification. Secondary polycythemia, as the name indicates, occurs secondary to certain underlying causes, which increase the oxygen demand of our body. [Full Text]. [Medline]. PV makes the spleen work harder to remove all the extra blood cells. Secondary polycythemia is caused by excess production of erythropoietin, the hormone that controls red blood cell production. The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era. We reviewed current guidelines on the management of polycythemia vera. Often, this type of polycythemia can be treated by addressing the cause of oxygen shortage. Polycythemia (also known as polycythaemia or polyglobulia) is a disease state in which the hematocrit (the volume percentage of red blood cells in the blood) and/or hemoglobin concentration are elevated in peripheral blood.. [Full Text]. What people are taking for it . Many people have no symptoms when they are first diagnosed with polycythaemia vera. Secondary polycythemia affects some people as a result of limited oxygen due to smoking or living at high altitudes. Clin Appl Thromb Hemost. Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management.